Objective evaluation of the effect of autologous platelet concentrate on post-operative scarring in deep burns

H. Klosová, J. Štětinský, I. Bryjová, S. Hledík, L. Klein

Burns, (2013), vol. 39, 6, p. 1263


Introduction: The healing of grafted areas after surgical treatment of deep burns\\r\\nfrequently generates mutilating scars, and rises the risk of subsequent scar hypertrophy.\\r\\nScar assessment based on clinical evaluation is inherently subjective, which stimulates\\r\\nsearch for objective means of evaluation. Objective: The aim of this study was to\\r\\nobjectively evaluate the effect of using autologous platelet concentrate (APC) in\\r\\ncombination with split thickness skin grafting (STSG) on scarring processes following\\r\\nsurgery of deep burns as compared with application of STSG alone. Method: Selected\\r\\nviscoelastic properties of 38 scars on 23 patients in total were examined using the\\r\\nCutometer MPA 580 under controlled conditions for long-term outcomes 1, 3, 6 and 12 months\\r\\nafter surgery following deep burns. Results: The findings of this study suggest that the\\r\\nSTSG + APC combination reduces the time of scar viscoelastic properties recovery as\\r\\ncompared with application of STSG alone. This was statistically significant for\\r\\nviscoelastic parameters R2 and Q1. Conclusion: APC has been advocated to enhance scarring\\r\\nafter surgery of deep dermal and full thickness burns. We objectively demonstrated that\\r\\nthe viscoelastic properties of scars treated with STSG + APC combination return more\\r\\nrapidly to the plateau state than areas treated with STSG only.